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lamina cribrosa (LC) and choroid is thinning in Alzheimer’s disease patients: enhanced depth imaging optical coherence tomography study

Poster Details

First Author: M.Eraslan TURKEY

Co Author(s):    S. Yildiz Balci   E. Cerman   O. Sahin   O. Cekic   D. Suer   E. Tuncer Elmaci

Abstract Details


Comparing lamina cribrosa (LC) and choroidal thickness using enhanced depth imaging optical coherence tomography (EDI-OCT) in Alzheimer’s disease patients(AH) and healthy subjects.


Marmara University School of medicine Department of Ophthalmology


Twenty eight eyes of 14 AH patients and 54 eyes of 27 healthy subjects was enrolled to the study. After a complete ophthalmic examination, all study eyes were imaged with OCT (RTVue-100 5.1 Fourier-Domain Optical Coherence Tomography-Optovue Inc., Fremont, CA). Severity was evaluated with Mini Mental State Examination test


The groups were matched regarding age, gender, refractive errors, intraocular pressure, axial length and central corneal thickness.The mean LC thicknesses were 207.8±29.4 µm in AD and 295.7±32.4 µm in control subjects.There was a significant difference between groups regarding mean LC thickness.(P <.0001)The choroidal thickness of AD group at subfovea, 1.5 mm temporal and 1.5 mm nasal to the subfovea was 218.9±26.9 µm, 186.2±19.8 µm and 176.1±27.4 µm, respectively. Whereas it was 253.6±41.2, 234.8±33.7, 217.0±43.7 in controls. There was a significant difference between groups regarding mean choroidal thickness. (P <.0001)


AD affect ophthalmic structures causing thinning in lamina cribrosa and choroid. Enhanced depth imaging technique may be used as an additional modality in diagnosis and follow-up of patients with AD. Imaging these changes with OCT may help in diagnosis and management.

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