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Comparison of central corneal thickness measurements in healthy eyes using three popular diagnostic devices

Poster Details

First Author: M.Unlu TURKEY

Co Author(s):    H. Akcam   A. Hondur           

Abstract Details


To compare the precision of central corneal thickness (CCT) measurements using Haag-Streit Lenstar LS900 optical biometry (Lenstar), Sirius Scheimpflug camera combined with Placido-disk corneal topography (Sirius), and Heidelberg anterior segment spectral-domain optical coherence tomography (AS-OCT) in healthy subjects.


Gazi University, Ankara, Turkey.


One eye from each of 75 subjects (43 male and 32 female; age, mean ± SD: 28.8 ± 8.58 years) was randomly selected for this study. The measurements of the CCT were taken with Lenstar, Sirius, and AS-OCT. Results were compared statistically using repeated-measures analysis of variance (ANOVA), Pearson’s correlation coef¬ficient, and the limits of agreement (LoA).


The average CCT was 505.73, 504.49, and 520.74 μm for Lenstar, Sirius, and AS-OCT respectively. Repeated-measures ANOVA showed a significant difference between the three methods (P=0.02). The ANOVA test revealed no statistically significant difference between Lenstar and Sirius (P=0.49), yet statistical signifi¬cant differences with Lenstar versus AS-OCT (P=0.03) and Sirius versus AS-OCT (P=0.01). The intraobserver repeatability analyses of variance are not significant for the all devices. There were high correlations between the three instruments (P<0.0001). The mean differences were 15.01, 16.25, and −1.24 for AS-OCT versus Lenstar, AS-OCT versus Sirius, and Sirius versus Lenstar, respectively.


The Heidelberg AS-OCT produces CCT measurements that vary significantly from those returned by the Lenstar and the Sirius, suggesting that the Heidelberg AS-OCT may not be used interchangeably with either equipment for monitoring the CCT in the clinical setting.

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