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Corneal perforation associated with topical indomethacin use in a patient with mixed connective tissue disease

Poster Details

First Author: S.khochtali TUNISIA

Co Author(s):    M. Hani   G. Hachicha   J. Nemria   S. Attia   S. Zaouali   M. Khairallah

Abstract Details


To report a case of spontaneous corneal perforation in a patient with mixed connective tissue disease, following long-term use of topical indomethacin.


Department of Ophthalmology of Fattouma Bourguiba University Hospital, Monastir, Tunisia.


A 37-year old female patient presented with spontaneous corneal perforation in the right eye. She had a history of mixed connective tissue disease, and was receiving a low dose of oral prednisone and hydroxychloroquine. She had also been on artificial tears and topical 0.1% indomethacin for several weeks for her dry eye. Corneal perforation was managed conservatively with topical antibiotics, lubricants, and bandage contact lens application. The corneal melt healed completely. Best-corrected visual acuity at 6-month follow-up was 20/200.


Corneal perforation may occur as a complication of excessive use of topical non-steroidal anti-inflammatory agents, in the setting of preexisting ocular surface diseases, particularly severe dry eye.



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