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Hemi-DMEK transplantation - A novel method for increasing the pool of endothelial graft tissue

Poster Details

First Author: L.Baydoun THE NETHERLANDS

Co Author(s):    F. Lam   M. Dirisamer   J. Lie   I. Dapena   G. Melles  

Abstract Details


To evaluate the clinical outcome of using a large diameter semicircular descemet graft in descemet membrane endothelial keratoplasty (hemi-DMEK), potentially allowing the use of a single donor cornea for two endothelial keratoplasty procedures.


The Melles Corneal Clinic: Tertiary referral centre


A prospective evaluation of the technical feasibility and clinical outcome of hemi-DMEK. Hemi-DMEK was performed in three eyes of three patients with Fuchs endothelial dystrophy. The main outcome measures were best corrected visual acuity (BCVA), endothelial cell density (ECD), pachymetry, and intra- and postoperative complications were recorded up to 6 months. BCVAs at 6 months were 20/28 (0.7), 20/40 (0.5; amblyopic eye) and 20/17 (1.2). At 1 month, ECD decreased 31-49%, and endothelial cell migration appeared to continue up to six months. Central corneal thicknesses decreased from 682-707 µm before surgery to 489-534 µm at 6 months. No intra- or postoperative complications were seen.


Hemi-DMEK (using half-moon shaped grafts) proved technically feasible and may give visual outcomes similar to those in routine DMEK (full-moon shaped graft). This technique may have the potential to double the availability of donor endothelial tissue for DMEK surgery



Financial Disclosure:

One or more of the authors receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented

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