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Effect of hemodialysis on corneal biomechanical properties in patients with end-stage renal disease

Poster Details

First Author: N.Yuksel TURKEY

Co Author(s):    N. Duru   M. Mutlu   H. Altinkaynak   U. Ozen   M. Turkyilmaz   N. Cagil     

Abstract Details


The aim of this study was to compare the biomechanical parameters of the cornea and intraocular pressure before and after hemodialysis (HD) in patients with end-stage renal disease (ESRD) and also healthy subjects.


Ankara Ataturk Education and Research Hospital, Department of Ophthalmology, Ankara, Turkey.


Twenty-one patients with ESRD undergoing HD treatment (study group) and 21 healthy individuals (control group) were enrolled in this prospective study. Right eyes of each subjects were included. Central corneal thickness (CCT) were measured using Sirius Scheimpflug camera. Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compansated intraocular pressure (IOPcc), and Goldmann-related intraocular pressure (IOPg) were measured using Ocular Response Analyzer (ORA). In study group, measurements were taken just before HD and 30 minutes after HD.


The mean CCT, CRF, IOPg values did not differ between pre-HD, post-HD and controls (p >0.05). CH was found to be significantly higher in control group (10.6 ± 1.2 mmHg) when compared to pre-HD (8.07 ± 1.8 mmHg) and post-HD (8.8 ± 1.6 mmHg) CH values (p < 0.001). While IOPcc did not differ after HD (p > 0.05), it was significantly lower in control group (p < 0.05).Significant correlations were seen between post-HD CRF and post-HD CCT (r=0.6, p < 0.05) ; and post-HD IOPg and post-HD CCT (r=0.51, p < 0.05).


ESRD may disrupt the biomechanical properties of the cornea. Changes in ORA parameters should be kept in mind to evaluate accurate IOP measurements in patients with ESRD.

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