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Correlation of vessel density changes in macular and peripapillary regions in healthy subjects after caffeine intake using OCTA

Poster Details

First Author: B. Yilmaz Tugan TURKEY

Co Author(s):                        

Abstract Details


To observe the effects of caffeine intake on vessel densities in macular and peripapillary regions and to analyze the correlations of vascular properties of these two interlinked regions in healthy volunteers using optical coherence tomography angiography (OCTA).


This study took place in the Department of Ophthalmology at Kocaeli University, Kocaeli, Turkey, between June 2020 and July 2020.


In this prospective randomized, double-masked, placebo-controlled study, 120 participants grouped into two: sixty subjects as a study group, which recieved caffeine, sixty subjects as a placebo group, which recieved placebo. A complete ophthalmologic examination, including; best corrected visual acuity, slit-lamp biomicroscopy, IOP and axial eye length measurement, spherical equivalent, dilated fundus examination were performed for all participants. Blood pressure and IOP measurements, OCTA imaging was performed at baseline and 1 hour after drug intake. Changes in macular and radial peripapillary capillary (RPC) vessel densities (VD), foveal avascular zone (FAZ) parameters and correlation of these densities with each other were analyzed.


SBP, DBP and IOP did not not show significant difference in two groups (p>0.05 for all) after drug intake. Baseline macular, RPC VD and FAZ parameters showed no significant difference between study and placebo groups (p>0.05 for all). In study group, vessel densities in all segments of superficial and deep macular regions and peripapillary region showed statistically significant decrease after caffeine intake (p<0.001 for all). All macular superficial VD parameters showed positive correlation with deep perifovea VD (p<0.05 for all). Also, superficial perifovea VD was positively correlated with all deep macular VD parameters except deep fovea VD (p<0.05 for all).


Caffeine administration decreased macular and peripapillary vessel densities in healthy volunteers and corrrelations were observed between macular and peripapillary vessel density parameters. Future studies are needed to support the effect of caffeine on peripapillary vessel density and idea using deep perifoveal vessel density as a main parameter to estimate superficial macular parameters.

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