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Evaluation of efficacy and safety of XEN 45 Gel Stent Implantation in pseudophakic glaucoma patients

Poster Details

First Author: J. Janiszewska- Salamon POLAND

Co Author(s):    J. Janiszewska-Salamon   M. Dorecka   E. Mrukwa-Kominek              

Abstract Details


To evaluate the efficacy and safety of XEN 45 Gel Stent implantation in patients with open-angle glaucoma after cataract removal


1 Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Poland; 2 Department of Ophthalmology, Professor K. Gibinski University Clinical Center of the Medical University of Silesia, Katowice, Poland


This is a retrospective case series. The patients who underwent the surgery with XEN 45 Gel Stent implantation with conjunctival injection of Mitomycin C at our hospital were included. All patients were treated for open-angle glaucoma with intraocular pressure inadequate for glaucoma control at the maximum tolerated local IOP-lowering treatment. Postoperatively, patients were assessed on days 1 and 7, and months 1,3,6 and 12. At each visit, intraocular pressure (IOP), the number of topical glaucoma medications, visual acuity and the presence of complications were analyzed.


34 pseudophakic patients (aged 58.3 οΎ± 15.8) with open-angle glaucoma were included. Mean pre- and postoperative IOPs were 26.6 mmHg, 10.0, 11.6, 13.0, 16.2, 15.4 and 15.8 respectively (p<0.05). Mean number of glaucoma medications were 2.8 and 1.6 respectively. Needling was required in 10 cases. We observed diffused blood in the anterior chamber in 11 cases, hypotension in 2 cases and displacement of XEN45 gen stent into anterior chamber in 1 case and under conjunctiva in 1 case.


Despite a relatively short follow-up period, XEN45 Gel Stent was associated with clinically and statistically significant reduction in IOP. The minimally invasive glaucoma surgery with XEN45 Gel Stent implantation is an effective method of lowering the intraocular pressure with a high safety profile. A longer follow-up period is needed.

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