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Clinical and microbiological effects of eye drops containing Polyvinyl alcohol 1.25%, dexpanthenol, hexamidine disethionate 0.05%, polyhexanhydrochloride 0.0001%, methylsulfonylmethane and disodium edetate on eyes suffering from keratoconjunctivitis

Poster Details

First Author: M. Troisi ITALY

Co Author(s):    S. Cirillo   S. Del Prete   S. Troisi              

Abstract Details


Evaluate bacterial culture results, efficacy on clinical symptoms and safety of Polyvinyl alcohol 1.25%, dexpanthenol, hexamidine disethionate 0.05%, polyhexanhydrochloride 0.0001%, methylsulfonylmethane and disodium edetate antiseptic eye drop solution on patients with suspected microbial keratoconjunctivitis. This formulation reportedly possess anti-infective and epitheliotrophic properties. The present study was undertaken to elucidate the role of this ophthalmic product in conjunctival inflammations associated with superficial punctate keratitis. Side effects, if present, were noted during the study.


Ophthalmologic Unit of Salerno Hospital University, Center of Ocular Surface Pathology (Salerno, Italy). Ethics Committee approval was obtained.


50 eyes of consecutive patients with suspected microbial keratoconjunctivitis without topical therapies at the moment were evaluated. Biomicroscopic examination, fluotest, BUT-test, OSDI questionnaire, microbiologic study for bacteria and fungi and sensitivity tests to antibiotics and antiseptic eye drops (inhibition halo greater than 10mm) were performed at zero time. The antiseptic formulation was prescribed every 6 hours, pending laboratory results. Diagnostic-therapeutic revaluation was conducted at 4-8-15 days, based on the clinical picture evolution and the microbiological culture identification.


42 on 50 cultures of conjunctival scrapings presented bacterial development (28 gram+, 10 gram-, 4 mixed flora); 1 case of candida infection was reported. The antiseptic eye drops were clinically effective on 36 eyes; 30 of 42 positive cultures presented antiseptic inhibition halo greater than 10 mm. In 15 cases, targeted antimicrobial therapy was associated for 7 days; in one eye the established therapy was not effective at 15 days. There were no side effects observed during the course of the study and the eye drop was well tolerated by all patients.


A clinical improvement with the antiseptic eye drop treatment was observed in 72% of the examined cases. Antiseptic eye drops showed antimicrobial activity in vitro on 71,4% of the isolated germs. Its use has shown good efficacy and tolerability in keratoconjunctival microbial infections and in punctate noninfective keratitis. The antiseptic eye drop has a useful role in infective and inflammatory kerato-conjunctival disorders.

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