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Seasonal patterns of incidence, demographic factors, and microbiological profiles of infectious keratitis: The Nottingham Infectious Keratitis Study

Poster Details

First Author: D. Ting UK

Co Author(s):    C. Ho   J. Cairns   B. Gopal   A. Elsahn   D. Said   H. Dua     

Abstract Details


To examine the seasonal patterns of incidence, demographic factors and microbiological profiles of infectious keratitis (IK) in Nottingham, UK.


A retrospective observational study at a UK tertiary referral centre.


A total of 1272 IK cases were included. all patients who were diagnosed with IK and underwent corneal scraping during 2008-2019 at a UK tertiary referral centre. Seasonal patterns of incidence (in per 100,000 population-year), demographic factors, culture positivity rate, and microbiological profiles of IK were analysed. Pearsonメs correlation coefficient (r) analysis was performed to examine the incidence of IK in each season over time and was interpreted as weak (r=0.00-0.40), moderate (r=0.41-0.69), or strong (r=0.70-1.00)


The overall incidence of IK was highest during summer (37.7, 95%CI: 31.3-44.1), followed by autumn (36.7, 95%CI: 31.0-42.4), winter (36.4, 95%CI: 32.1-40.8), and spring (30.6, 95%CI: 26.8-34.3), though not statistically significant (p=0.14). The incidence of IK during summer increased significantly over the 12 years of study (r=0.58, p=0.049), but the incidence of IK in other seasons remained relatively stable throughout the study period. Significant seasonal variations were observed in patientsメ age (younger age in summer) and causative organisms, including Pseudomonas aeruginosa (32.9% in summer vs. 14.8% in winter; p<0.001) and Gram-positive bacilli (16.1% in summer vs. 4.7% in winter; p=0.014).


The incidence of IK in Nottingham was similar among four seasons. No temporal trend in the annual incidence of IK was observed, as reported previously, but there was a significant yearly increase in the incidence of IK during summer in Nottingham over the past decade. The association of younger age, P. aeruginosa and Gram-positive bacilli infection with summer was likely attributed to contact lens wear, increased outdoor/water activity, and warmer temperature conducive for microbial growth.

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