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Sirius meibography: easy and effective method

Poster Details

First Author: K.Gumus TURKEY

Co Author(s):    D. Gulmez Sevim   M. Unlu                 

Abstract Details


To evaluate the correlation between clinical quantifying of meibomian gland dysfunction (MGD) grade and meibomian gland area (MGA) loss detected with Sirius meibography in upper and lower eyelids and correlation of these parameters with dry eye signs and symptoms.


Erciyes University Faculty of Medicine, Department of Ophthalmology, Kayseri, Turkey


One hundred thirty eyes of 130 volunteered subjects were enrolled. MGD was defined as the presence of signs consistent with meibomian gland terminal duct obstruction and categorized between grades 1 and 4. The ocular surface disease index (OSDI) questionnaire was completed and ocular surface tests consisted of tear break-up time (BUT) and ocular surface staining with lissamine green (LG). Upper and lower MGA loss percent were evaluated using Sirius meibography. Participants were categorized into two groups (positive and negative for MGD) based on their OSDI scores (≥15 and <14, respectively) and MGD grades (≥1 and 0, respectively).


MGA loss percent and ocular surface test results of the MGD group was greater than non-MGD group in both eyelids (p=0.001). MGD grade and MGA loss for the lower eyelid was greater than that of the upper eyelids (p=0.002, p<0.001 respectively). MGA loss was correlated with MGD grade in lower and upper eyelids (r=0.82, p<0.001 and r=0.54, p<0.001). MGD grade and MGA loss in lower eyelids were correlated with age (r=0.214, p=0.015 and r=0.24, p=0.005). OSDI score, TF-BUT and LG staining were all significantly correlated with MGD grade and MGA loss in both eyelids (p<0.001).


We found that MGD grades showed strong correlations with MGA loss in both eyelids, and lower eyelids showed greater MGD grade and MGA loss compared to upper eyelids. MGD grades and MGA loss are significantly correlated with TF-BUT and LG staining of ocular surface and OSDI scores. Aging was positively correlated with MGD grade and MGA loss in lower eyelids when adjusted for sex. Our findings suggest that Sirius meibography, a non-contact imaging device, is a reliable tool for evaluating meibomian gland structure in the group of MGD and non-MGD participants of various ages and sex.

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