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Caveats of collagen application on glaucoma

Poster Details

First Author: S.Rho SOUTH KOREA

Co Author(s):    M. Lee   M. Lee   C. Lee              

Abstract Details


To describe caveats of collagen applications on glaucoma by assessing the influence of a biodegradable collagen matrix implantation with Ahmed glaucoma valve in human and rabbits


Observational clinical study based on laboratory research, CHA Bundang Medical Center, CHA University


A total of 68 refractory glaucoma eyes, followed up postoperatively for at least 6 months, were consecutively enrolled after retrospective chart review. The BCM-augmented Ahmed valve implantations (BAAVI) using two types of BCM (so-called Ologen-6 and Ologen-7) were performed and compared with a conventional method. The biological properties of each BCM were assessed by enzymatic degradation rates via collagenase under ocular physiological conditions. The histologic slides in New Zealand white rabbits were obtained at 2 months after AGV implantation with or without BCM and assessed using Masson Trichrome stain.


The success rates were higher in Ologen-7 than Ologen-6 BAAVI group. The enzymatic degradation rate of Ologen-7 was significantly slower than that of Ologen-6 (12.5 x 10-3 vs. 28.8 x 10-3). The thickness of the fibrous capsule (roof) around the implant was thinner in the study group (Ologen + AGV, 251.89 ± 128.47 ㎛) than in the control group (AGV only, 625.66 ± 30.06㎛) in rabbit histologic slides.


The success rates of BAAVI were different according to the types of BCM and it might be related to enzymatic degradation rate or fibrotic responses after AGV implantation. It may be because the application of BCM on AGV can modify the bleb fibrosis which can lead to bleb morphology change after AGV surgery.

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