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Prospective evaluation of XEN gel implant in eyes with pseudoexfoliative glaucoma

Poster Details

First Author: K.Mansouri SWITZERLAND

Co Author(s):    J. Guidotti   H. Rao   A. Ouabas   A. Mermoud           

Abstract Details


To compare the safety and efficacy of XEN gel implant surgery (Allergan Inc., Irvine, USA) in patients with pseudoexfoliative glaucoma (PEXG) and primary open angle glaucoma (POAG).


Prospective, interventional study in a tertiary glaucoma center (Glaucoma Center, Montchoisi Clinic, Swiss Vision Network, Lausanne)


Fifty-seven eyes (43 patients) with POAG and 53 eyes (42 patients) with PEXG with uncontrolled intraocular pressure (IOP) despite medical treatment underwent combined XEN+cataract surgery or standalone XEN surgery. Mean IOP, mean number of medications at 1-year follow-up, needling rates, and incidence of adverse effects (AE) were analyzed. Complete success, defined as an IOP lower than 16 mmHg without medications at 1 year, was also analyzed.


Combined XEN+cataract surgery was performed in 72% of POAG and 75% of PEXG eyes (p=0.674). Patient characteristics were similar between the two groups except for higher age for the PEXG patients (78.5±8.5 vs 71.3± 8.7 years; p<0.001). Mean IOP was 19.8±5.8 (POAG) and 19.7±8.2 (PEXG) at baseline (p=0.98) and 13.9±4.6 and 13.6±4.3 mmHg at 1 year (p=0.87), respectively (p<0.01). Mean medications dropped from 1.9±1.6 (POAG) and 2.0±1.3 (PEXG) preoperatively to 0.4±0.8 and 0.5±0.8, respectively at 1 year (p<0.001).42% (POAG) and 63% (PEXG) eyes achieved year-1 complete success (p=0.06).


The XEN gel implant as a standalone or combined procedure demonstrated similar efficacy and safety results in PEXG and POAG eyes.

Financial Disclosure:

receives consulting fees, retainer, or contract payments from a competing company

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