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High-intensity focused ultrasound cycloplasty: changes in pupil behaviour

Poster Details

First Author: L.Abegao Pinto PORTUGAL

Co Author(s):    D. Cordeiro Sousa   N. Pinto Ferreira   C. Marques-Neves   A. Sommers   E. Vandewalle   I. Stalmans     

Abstract Details


High-intensity focused ultrasound cycloplasty (UCP) aims to achieve selective coagulation of the cilliary body, thus reducing aqueous humor production and lowering intraocular pressure (IOP). The potential effect on pupil behavior should be studied to better inform patients and to help physicians predict possible treatment side effects. This study aimed to evaluate to what extent UCP procedure (EyeOP-1®) affects pupil dynamics.


Hospital de Santa Maria, Lisboa, Portugal. Glaucoma Clinic UZ Leuven, Leuven, Belgium.


Consecutive glaucoma patients with uncontrolled IOP despite optimal medication were scheduled for UCP treatment and followed for 6 months. Pupillometry (PlusoptiX® S04) was performed at baseline, and 1, 3 and 6 months after UCP procedure at scotopic and mesopic conditions, with the difference between pupil diameter (PD) in both lighting conditions calculated in all timepoints. Demographic and clinical characteristics, and specific ocular parameters (visual acuity, anterior chamber depth and volume, white-to-white measurement, axial length, phakic status) were registered. Statistical analysis were performed using STATA 14.1.


Sixteen eyes of 16 patients with a mean age of 69 ± 11 years were included. Mean preoperative IOP and number of medications were 23.6 ± 3.0 mmHg and 2.4 ± 1.3, respectively. Baseline mean scoptopic and mesopic PD were 4.8 ± 0.8 mm and 4.4 ± 0.9 mm, respectively (difference = 0.38±0.30 mm). At month-1, the PD change between scotopic and mesopic conditions decreased to 0.03±0.34 mm, p=0.01. On the other hand, in longer follow-up periods, the amplitude in PD compared to baseline was not significant (month-3: 0.28±0.49 mm; month 6: 0.23±0.41 mm; p>0.05). No subjective complaints were noted.


A heterogeneous pupil response occurs after UCP treatment. Most patients presented a less light-reactive pupil in the early post-op period, a response which seems to partially disappear with time.

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