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Comparison of capsulotomy first to fragmentation first in laser cataract surgery

Poster Details

First Author: L.Schwarzenbacher AUSTRIA

Co Author(s):    D. Schartmueller   C. Leydolt   R. Menapace              

Abstract Details


Controversy exists regarding topical non-steroidal anti-inflammatory drug (NSAID) pretreatment before Femtosecond Laser-assisted Cataract Surgery (LCS). We are performing a prospective, intraindividual, randomized study to learn about intraoperative miosis and prostaglandin release in LCS with a low-energy, high-frequency laser device, and its dependency on the sequence of anterior capsulotomy and lens fragmentation.


Department of Ophthalmology, Medical University of Vienna


140 eyes of 70 patients with age-related cataract are included in this prospective study. Patients’ eyes are randomized into two groups, each eye receiving either capsulotomy before lens fragmentation in one eye and vice versa in the contralateral eye. No NSAIDs are administered preoperatively. Aqueous humor (AH) is extracted exactly 5 minutes after laser treatment in both groups. The pupil width is measured before LCS, directly after LCS and 5 minutes after LCS. All samples of AH are analyzed in the same laboratory with Enzyme-linked Immunosorbent Assay (ELISA) Kits for total-prostaglandin.


Total-prostaglandin will be presented in pg/ml based on the sequence of anterior capsulotomy and lens fragmentation. Pupil width will be measured in mm at 3 time points (before, after and 5-min after LCS). AH samples are being collected for prostaglandin evaluation in the laboratory. Results will be presented.


No conclusions can be drawn at this moment due to incomplete data acquisition. In order to guarantee comparable prostaglandin values all samples need to be analyzed in one ELISA examination under identical conditions.

Financial Disclosure:


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