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Predictors affecting myopic regression in more than -10.0D myopia after laser-assisted sub-epithelial keratomileusis and laser in situ keratomileusis flap creation with femtosecond laser-assisted or mechanical microkeratome-assisted

Poster Details

First Author: Z.Jihong CHINA

Co Author(s):                        

Abstract Details


All patients recruited had a manifest SE more than -10.0D myopia. To compare the predictive factors of postoperative myopic regression among subjects who have undergone laser-assisted subepithelial keratomileusis (LASEK), laser-assisted in situ keratomileusis (LASIK) flap created with a mechanical microkeratome (MM) and flap created with a femtosecond laser (FS). A predictive model of postoperative myopic regression would be derived from the study that could provide an accurate tool to estimate an individual’s affective factors in laser refractive surgery.


Beijing Aier-Intech Eye Hospital, Beijing, China.


Retrospective comparative study. The study enrolled 264 eyes in LASEK group, 178 eyes in FS-LASIK group; and 120 eyes in MM-LASIK group. Refractive outcomes were recorded at1day,1week, 1, 3, 6, and 12 months postoperatively. A Cox proportional hazards model was used to evaluate the impact of the three types of surgeries and other covariates on postoperative myopic regression. Myopic regression was defined as residual myopia < -0.50 D and a > 0.50-D shift toward myopia during the follow-up visits.


The survival rates were 36.64%, 38.79% and 29.01% in the MM-LASIK, FS-LASIK, and LASEK groups respectively at 12 months. Risk factors included thicker post-operative central corneal (RR=1.01, P< 0.01, 95%CI=0.98,1.02), older age (RR=1.02, P< 0.01, 95%CI=1.00, 1.04); thicker preoperative central corneal (RR=0.99, P< 0.01, 95%CI=0.98, 1.00), lower preoperative myopia (RR=0.83, P < 0.01, 95%CI=0.74, 0.92) were protective factors. The probability of postoperative myopic regression was not different in three groups (P = 0.06).


Rates of postoperative myopic regression was high among LASEK, MM-LASIK and FS-LASIK groups in more than -10.0D myopia. Older age, thicker post-operative central corneal thickness contributed myopic regression; thicker preoperative central corneal thickness, lower manifest refraction SE would prevent postoperative myopic regression. The model originated from the study was created to predict postoperative myopic regression more than -10.0D myopia.

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