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Vienna 2018 Delegate Registration Programme Exhibition Virtual Exhibition Satellites 2018 Survey


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Clinical prevalence of familiar association in keratoconus (KCN): tomographic evaluation of KCN patient parents

Poster Details

First Author: V.Skouteris GREECE

Co Author(s):    A. Kanellopoulos                    

Abstract Details


To try and identify suspicion or clinical keratoconus in known KCN families.

Setting: Clinical and Research Eye Institute, Athens, Greece


In a prospective study, 165 keratoconus patients had their parents imaged by Scheimpflug tomography mapping. The tomographies were reviewed by an independent, blinded to the process expert observer for known and also suspicious signs of early ectasia.


The study included 34 (21%) female and 131 (79%) male known KCN subjects. Mean age was 25 ± 7 years (range, 15-45 years). KCN or suspicion for KCN was identified in one of the two parents evaluated in 90.6% of these cases and in both parents in 8% of the cases.


KCN inheritance pattern in the Greek population appears to be significantly greater than the percentages known so far. Further genetic testing may confirm or even amplify these data. Clinical relevance dictates close screening for KCN in all families with a KCN member and appropriate caution in laser refractive surgery given to the potential of ectasia.

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