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Effect of the bio protectant agent trehalose on corneal epithelial healing after corneal cross-linking for keratoconus

Poster Details

First Author: E.Karaca TURKEY

Co Author(s):    D. Ozek   O. Evren Kemer                 

Abstract Details


The purpose of this study is to compare efficiency of sodium hyaluronate (SH) to trehalose and sodium hyaluronate combination (TH-SH) eye drops for treatment of corneal cross-linking (CXL) patients' epithelial healing.


Health Sciences University, Ankara Numune Training and Research Hospital


This study includes 46 eyes of 23 keratoconus patients, who were CXL operated on both eyes. Unpreserved trehalose 30 mg/mL and sodium hyaluronate 1.5 mg/mL (Thealoz Duo®;Thea, France) was applied six times a day on one eye of each patient, whereas unpreserved sodium hyaluronate, 0.15% (Eye still®; Teka, Inc., Istanbul) was applied on the other eye. Patients were examined daily until complete re-epithelialization. Postoperative examinations included slit-lamp biomicroscopy to assess the epithelial defect size measured.


Mean age of 13 female and 10 male patients was 20.9±10.3. Corneal epithelial healing after cross-linking was 2.3±1.2 and 3.8±2.9 days for TH-SH group and SH group respectively (p=0.03).


Trehalose and sodium hyaluronate combination drop instillation was observed to result in faster corneal re-epithelialization after CXL compared to SH drop alone in this study.

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