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Late onset peripheral ulcerative keratitis post corneal collagen cross-linking

Poster Details

First Author: W.Chanbour LEBANON

Co Author(s):    E. Jarade                    

Abstract Details


To report and investigate the risk factors and the treatment of peripheral ulcerative keratitis, a new complication occurring post Collagen Cross Linking (CXL)


the study was conducted in Beirut Eye And ENT specialist Hospital including keratocunus patients presenting for surgery between January 2010 and December 2016


A retrospective study including 474 eyes of 294 patients Their medical files, visual acuities, operative reports and post-operative follow up were reviewed. The CXL with riboflavin Ultraviolet A light were performed by the same surgeon with the assistance of the same nurse. Chi square test (Fisher's Exact Test) and independent t-test were used to compare the variables. A P-value <0.05 was considered statistically significant.


10 eyes of 7 patients (2.1%) developed a late onset peripheral ulcerative keratitis with or without corneal haze and sterile infiltrates. The complications occurred between 3 months and 6 years post-op. Their mean age of 41 ±6.4 years was higher than the age of the patients with non-complicated surgery 22.25± 8.5 years (p=0.001). Three patients had autoimmune conditions. The sex, the presence of intra stromal ring segments, the keratometry and the thinnest pachymetry were found to be non-significantly different between both groups. All patients responded positively to steroid treatment, only one had a relapse which resolved with cyclospirne drops.


Long term follow up post CXL is necessary to uncover the late onset peripheral ulcerative keratitis. It is a treatable condition associated older age and autoimmune conditions but has a good visual outcome.

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