Official ESCRS | European Society of Cataract & Refractive Surgeons
Vienna 2018 Delegate Registration Programme Exhibition Virtual Exhibition Satellites 2018 Survey


escrs app advert


Search Title by author or title

Clinical efficacy and microscopic changes of four corneal cross-linking techniques in the treatment of keratoconus

Poster Details

First Author: Q.Zeng CHINA

Co Author(s):    P. Song                    

Abstract Details


To compare the clinical efficacy of three kinds of transepithelial corneal cross-linking (CXL) and epithelium-off corneal corss linking in the treatment of keratoconus.


Hankou Aier Eye Hospital, retrospective self-control study.


Sixty-seven eyes of fifty-eight patients with keratoconus were enrolled, 9 patients received epithelium-off CXL, 14 patients received hypotonic CXL, 13 patients received iontophoresis CXL (I-CXL) for 5 minutes, 22 patients received iontophoresis CXL for 10 minutes. Preoperative and postoperative results of visual acuity, corneal tomography, optical coherence tomography, laser scanning confocal microscopy were collected used for statistical analysis.


At 12 months postoperatively, UDVA and CDVA improved significantly in 10 minutes I-CXL group. Kmax value remained stable in all four groups (all P>0.05). Subbasal nerve density in hypotonic CXL group did not change significantly, while the decreases in the other three groups were significant at 1, 3, and 6 months, and didn’t regain at 12 months in the epithelium-off group. The anterior stromal cells densities were decreased in all groups, especially in epithelium-off group and 10 minutes I-CXL group. The demarcation was deepest in epithelium-off group, followed by 10 minutes I-CXL group.


Standard epithelium-off CXL and I-CXL for 10 minutes. could effectively halt the progression of keratoconus with similar microscopic corneal changes. Hypotonic CXL and I-CXL for 5 minutes show less effects on the cornea and need further long observation.

Financial Disclosure:


Back to Poster listing