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Safety and clinical outcomes of novel micro-incision DMEK

Poster Details

First Author: F.Cabrerizo Nunez DENMARK

Co Author(s):    I. Potapenko   M. Alberti                 

Abstract Details


To evaluate safety and clinical outcomes of DMEK procedure carried out with a novel injector using a 1.1mm incision.


Dept. of Ophthalmology, Glostrup Hospital, Rigshospitalet, Copenhagen.


Seventeen consecutive patients (mean age 74.8±9.8 years) scheduled to undergo either stand-alone DMEK (n=12) or triple procedure (n=5) were enrolled in the study. Causes of endothelial dysfunction were: Fuchs endothelial dystrophy – 11 patients; pseudophakic bullous keratopathy - 2; re-DMEK - 2; other etiologies - 2). Surgery was performed using a novel DMEK injector through a 1.1mm corneal incision. Clinical outcomes and adverse events were recorded during postoperative follow-up of up to three months. Ex vivo, 12 DMEK grafts were passed through the injector and underwent scanning electron and confocal microscopy to assess morphological and cellular changes.


Best spectacle corrected visual acuity improved from 0.31 ± 0.21 pre-operatively to 0.65 ± 0.20 three months after surgery (n=7). This corresponded to a reduction in central corneal thickness from a mean of 679±104um to 598±88um one month after surgery. Mean postoperative endothelial cell density was 1404±305 cells/mm2. No remarkable morphological changes were observed in the DM by ex vivo microscopy. In eyes without previous corneal surgery induced astigmatism was 0.02 ± 1.18D (n=12). One of the patients developed post-operative intraocular pressure elevation. No other serious adverse events were encountered during the observation period.


Micro-incision DMEK is a safe procedure, with visual outcomes, endothelial cell survival and graft function comparable to standard DMEK.

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