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Combined amniotic membrane and platelet-rich plasma clot for management of central corneal perforation

Poster Details

First Author: A.Abdelghany EGYPT

Co Author(s):    M. El Bahrawy   J. Alio                 

Abstract Details


To report the added value in clinical and anatomical outcomes of using a platelet rich plasma clot in addition to amniotic membrane in the surgical management of perforated corneas.


Ophthalmology Department, Faculty of Medicine, Minia University, Minia, Egypt


This case series included 4 patients; 75% males with average age of 43.25 years ± 13.25 presented with central corneal perforation after failure of treatment of corneal abscess with antibacterial or antifungal agents, they underwent temporary closure with a company prepared dried amniotic membrane graft under general anesthesia due to unavailability of corneal grafts, covering the perforation, a freshly prepared platelet rich plasma clot from patient’s autologous serum was implanted filling the space between the graft and the perforation. Follow ups were at 2 weeks and then at 1 month using slit lamp and anterior segment OCT.


On the 2 weeks follow up, all patients showed marked improvement in the inflammatory signs with stability of anterior chamber. After one month, anterior segment OCT revealed complete closure of the perforation as the clot resolved with minimal corneal vascularization and digital IOP stability.


Adjuvant treatment with platelet rich plasma clot with amniotic membrane grafts in cases of the central corneal perforation has markedly improved the time of corneal defect closure , with better anterior chamber stability and less corneal vascularization and inflammation, when compared with using amniotic membranes alone

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