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Corneal imaging in granular dystrophy: a case report

Poster Details

First Author: A.Vicente SWEDEN

Co Author(s):    A. Viberg   B. Bystrom                 

Abstract Details


To present a case report of a patient with hereditary granular dystrophy with a special emphasis on corneal imaging.


Department of Clinical Science, Ophthalmology, UmeƄ University.


Visual acuity, intraocular pressure and pachymetry were recorded. Biomicroscopy and fundoscopy were performed. The patient also did videokeratography (Pentacam, Oculus, Germany), corneal endothelial specular microscopy and anterior segment photography. Anterior segment optical coherence topography (OCT) was done with Spectralis - Anterior Segment Module (Heidelberg Engineering, Germany). Confocal scanning laser ophthalmoscopy was performed using a Heidelberg Retina Tomograph equipped with a Rostock Cornea Module (Heidelberg Engineering, Germany).


A 21 years-old patient with granular dystrophy was referred to the cornea outpatient clinic. Biomicroscopy revealed unsymmetrical bilateral anterior-stromal round deposits which did not affect the epithelium, typical of granular corneal dystrophy (Groenouw I). Follow-up has been secured for 3 years. A slow progression with an increase of the number and size of deposits was documented. Best corrected visual acuity in OD remained stable at 0.8 and has decreased in OS from 1.0 to 0.7. The OCT and confocal microscopy showed "breadcrumb" opacities in the anterior 2/3 of the stroma. Discrete opacities in the posterior stroma were also found.


Both confocal microscopy and anterior segment OCT imaging have an important role in the diagnosis and follow-up of patients with granular corneal dystrophy (Groenouw I). The combination of these two imaging methods with slip-lamp photography may constitute an alternative to genetic and histopathological testing.

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