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Use of ozone-based eye drops: a new approach to treat some ocular pathologies

Poster Details

First Author: L.Spadea ITALY

Co Author(s):    E. Tonti                    

Abstract Details


Based on the many features and possible applications of ozone, aims of the present study is an evaluation of a new liposomal ozonated oil formulation plus hypromellose, specifically developed for ophthalmic use, instilled 4 times a day to promote wound healing and treat some infective pathologies in common eye disorders encountered in humans.


Eye Clinic, “A. Fiorini” Hospital, Sapienza University of Rome, Terracina (Latina), Italy


A 33-years-old man with a history of use of contact lens presented with pain and redness in one eye. Evaluation revealed conjunctival hyperemia and inferior corneal abrasion. A 79-years-old woman presented with eye pain and discharge in one eye. Examination revealed band keratopathy complicated by inferior corneal superficial ulcer. A 71-years-old man with a history of previous herpes related corneal ulcer referred because of pain in one eye. Evaluation showed area of stromal keratitis with stromal infiltrate and central corneal ulcer. A seven days therapy with ozonated oil formulation four-times-a day was prescribed in all the mentioned cases.


Three days later the 33-years-old patient came to our attention without any ocular discomfort and the examination showed a clear cornea, good healing of the defect and no sign of inflammation. Post treatment evaluation of 79-years-old women revealed improvement of clinical signs with reduction of the infiltrate and the edema, moreover a partial healing of the ulcer with a residual corneal pooling using the cobalt blue filter was shown. Regarding the related symptoms only a slight photophobia remained. Corneal involvement of the 71-years-old man was more circumscribed, signs of staining satisfactorily resolved with significant reduction of photophobia and glare symptoms.


Ozonated oil formulation drops seem to be safe and effective in the treatment of some ocular surface disorders, like conjunctivitis, keratitis, keratoconjunctivitis and corneal ulcers with positive results.

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