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Effectiveness of platelet-rich plasma and 0.01% sulfated glycosaminoglycans for treatment of chronic corneal erosions, associated with herpetic keratitis

Poster Details

First Author: A.Loshkareva RUSSIA

Co Author(s):    D. Maychuk                    

Abstract Details


To estimate effectiveness of platelet-rich plasma (PRP), isolated or in combination with 0,01% sulfated glycosaminoglycans, for treatment of herpetic recurrent cornea erosion syndrome with previously unsuccessful courses of reparative treatment.


Therapeutic Ophthalmology Department. Svyatoslav Fyodorov State Institution Eye Microsurgery Complex, 59A Beskudnikovskii Blvd, 127486, Moscow, Russia.


2 groups of patients (60 eyes) with recurrent corneal erosion syndrome and one-side Herpetic keratitis in anamnesis, age 48,4±9,7 were included. At first step all had antiviral therapy (Gancyclovir 0,15%, Valcyclovir 500mg.). At 2-nd step patients were divided in 2 groups and vein blood with Sodium citrate and Dextrosa subjected to double centrifugation, 4 min. at 3500 rpm, was used. 1-st group was receiving PRP instillations 6 times daily. 2-nd group - PRP in the combination with 0,01% sulfated glycosaminoglycans. Additional therapy included Dexpanthenol 5%. Dynamic of treatment was assessed by Efron scale. Condition before treatment was used for control.


Index of the corneal lesion before treatment was 7,1±1,9 at the 1-st and 6,9±1,8 points at the 2-nd group. After 8 weeks of treatment is was 2,1±2,1 and 1,9±2,2 points in groups. Full corneal epithelialization was observed at 14 patients in the 1-st group, at 15 patients in 2-nd group. All other patients in groups had positive dynamic and corneal lesion depression, but had no full epithelialization. An equivalent improvement in both groups was noted.


Comparative analysis with standard methods of therapy featured positive dynamic in groups with PRP treatment.

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