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Ocular involvement in granulomatosis with polyangiitis: a review of five cases

Poster Details

First Author: O.Barut Selver TURKEY

Co Author(s):    M. Palamar   S. Egrilmez   A. Yagci              

Abstract Details


To report the outcome of patients with granulomatosis with polyangiitis ocular involvement.


Ege University, Ophthalmology Department


Case series


We reviewed a series of five patients (M/F=3/2) with the mean age of 47.40 (34-65). Upon ocular involvement, the mean diagnosis time for the disease was 43.75 (1-96) months. Ocular involvement locations were cornea and sclera in three patients (one with accompanying uveitis and one with an orbital mass), sclera in two patients (one with an orbital mass). The initial diagnosis was made with the ocular involvement in four patients. The mean follow-up time was 2.62 (1-9) years. All patients were managed with local and systemic immunosuppressive treatments. Although ocular involvement regressed in four patients, one patient experienced phthisis bulbi.


Ophthalmologic involvement of granulomatosis with polyangiitis occurs in nearly half of the patients and causes serious morbidity. Uveitis is the least common form of ocular manifestations. Clinicians should recall granulomatosis with polyangiitis when there is presence of unexplained orbital inflammatory disease, scleritis, peripheral ulcerative keratitis, cicatricial conjunctivitis, nasolacrimal duct stenosis, retinal vascular occlusion, or infrequently uveitis.

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