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In vivo confocal microscopy of morpho-functional correlation and surgical outcome of filtering blebs in glaucoma patients: 2 year follow-up

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Session Details

Session Title: Presented Poster Session: Training & Quality of Vision

Venue: Poster Village: Pod 3

First Author: : S.Bagaglia ITALY

Co Author(s): :    P. Frezzotti                       

Abstract Details


The aim of the present study was to correlate the preoperative conjunctival globet cells density and Microcysts area pre operatively, using in vivo laser scan confocal microscopy (ILSCM) to functional outomes in glaucomatous patients treated by Augmented Mitomycne Trabeculectomy. 2 years follow up


University of Siena, Departement of Opthalmology, Viale Bracci Siena


24 eyes of 24 patients where evaluated with ILSCM conduced on upper bulbar conjunctiva, pre operatively, at1 month, 3 months, 6 months, 12 months,24 months after trabeculectomy.ILSCM examination was oriented to calculate number of Goblet Cells, Microcistys, and filtering bleeb outocomes. Surgery was considered successful when at least 30% reduction from preoperative IOP was obtained at 12 months. Eyes that met the above criteria and were not on supplemental anti-glaucoma medical therapy were defined as achieving a complete success eyes that met the criteria with supplemental medical therapy were defined as achieving a qualified success


Patients with a complete surgical success presented with higher preoperative GCD, compared to patients with a qualified success or failure. Patients with a successful surgery showed higher postoperative Microcyst Density compared to failed cases at 2 years follow up


Globet Cells and microcysts density could be proposed as a potential in vivo biomarker to predict the surgical outcome and to guide clinician to the appropriate time of surgery, and in the postoperative bleb management.

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