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Vienna 2018 Delegate Registration Programme Exhibition Virtual Exhibition Satellites 2018 Survey


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Corneal characteristics in Down syndrome patients

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Session Details

Session Title: Cornea Miscellaneous

Session Date/Time: Monday 24/09/2018 | 16:30-18:00

Paper Time: 17:15

Venue: Room A3, Podium 3

First Author: : A.Vega-Estrada SPAIN

Co Author(s): :    J. Alio   P. Sanz Diez   A. Osman   A. Mustafa Kamal           

Abstract Details


To characterize the main features of the cornea in patients with Down syndrome


Vissum, Alicante, Spain. Division of Ophthalmology, Miguel Hernández University, Alicante, Spain. Cairo University, Egypt.


multicentric study we included a total of 217 eyes of 110 patients with ages ranging from 60 to 1 year (mean age of 23.3 ± 13.8 years). All cases were divided into two groups according to the level of cooperation that had patients during eye examination. The cooperative group consisted in cases that underwent a full ocular examination, refraction, fundoscopic exam, topography, aberrometry examination and axial length measurement. The uncooperative group consisted in cases that who had a full ocular examination, refraction, fundoscopic exam but they were totally uncooperative to perform topography and aberrometry or axial length mesurements.


Results: DS group consisted of 112 subjects, with mean age of 14.88 ± 15.76 years and control group was made up of 105 subjects with healthy corneas. Significant differences were found in keratometry steepest meridians 47.30 in DS group vs 43.75 in controlgroup (p< 0.01), in corneal pachymetry 502 microns in DS group vs 545 in control group (p<0.01) in values of corneal shape in anterior and posterior surface and in the anterior and posterior corneal aberrometric variables such as higher order aberrations, primary coma, and coma-like aberrations (p<0.01).


Patients with Down syndrome have steeper anterior and posterior corneal surfaces, thinner pachymetries and more corneal aberrations than those patients without genetic alterations and normal corneas. High prevalence of corneal morphological alterations similar to those found in keratoconus may be observed in Downs Syndrome patients.

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