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Evaluation of topical human epithelial growth factor for treatment of epithelial defect

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Session Details

Session Title: Cornea Miscellaneous

Session Date/Time: Monday 24/09/2018 | 16:30-18:00

Paper Time: 16:36

Venue: Room A3, Podium 3

First Author: : J.Ashar INDIA

Co Author(s): :                        

Abstract Details


To evaluate the efficacy and safety topical preparation of Human epithelial growth factor drops in management of epithelial defect due to various etiologies


Mumbai Eye Care


20 patients/ 37 eyes with epithelial defect due to post Photorefractive keratectomy (17), infective keratitis (1), post cornea transplant (2) recieved human epithelial growth factor drops along with other standarad treatment in the form of steroid antibiotic combination and lubricating drops post PRK and keratoplasty and antibiotic drops for infective keratitits. The size of the epithelial defect was measured on first day and every consequtive day till resolution of the defect. Patients comfort with drops and pain was graded from 0 to 10, 0 being no pain to 10 being severe pain.


The mean epithelial defect size after PRK was 8.2mm on day 1 and decreased to less then 1.4 mm on day 2 and 0 on day 3 in all cases. This was a faster recover compared to historical controls where these drops were not used post PRK. The patients did not complain any discomfort with the drops. The pain on day 1 was 8 and on day 2 it was 0. In case of post transplant the epithelial defect resolved after 8 days and in infective keratitis it resolved in 15 days.


Human epithelial growth factor drops can help hasten the recovery of corneal epithelial defect after PRK. This decreases the pain after the procedure.

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