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Vienna 2018 Delegate Registration Programme Exhibition Virtual Exhibition Satellites 2018 Survey


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Combined topography-guided photorefractive keratectomy and topography-guided corneal cross-linking with oxygen supplementation in keratoconus: pilot study

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Session Details

Session Title: Cross-Linking Protocols

Session Date/Time: Monday 24/09/2018 | 14:00-16:00

Paper Time: 14:06

Venue: Room A3, Podium 3

First Author: : C.Kranemann CANADA

Co Author(s): :                        

Abstract Details


To determine the effectiveness and safety of topography guided crosslinking (Topo-CXL) with topography guided photorefractive keratectomy (Topo-PRK) with oxygen supplementation.


Clearview Institute Refractive Clinic


30 eyes with keratoconus were prospectively enrolled to undergo Topo-PRK (60 micron removal) with Mitomycin and consecutive Topo-CXL with Oxygen supplementation. A standard CXL safety protocol was utilized. All eyes underwent pre and post operative cycloplegic and manifest refractions/corneal and total eye wavefronts/topographies and Tear Osmolalities at mongth 1,3, 6 and 12. Adverse effects including delayed epithelial healing, haze, infection and intraocular pressure (IOP) spikes were recorded.


30 eyes of 18 patients were enrolled. The postoperative mean uncorrected visual acuity was 20/28 and corrected visual acuity was 20/22 (P<.01). The cylindrical correction ranges from 3.7 to 6.7 with a mean of 5.3 diopters. There was progressive improvement over the first 6 months and a smaller improvement (0.75) over months 6 to 12. None of the eyes showed clinically significant haze and only 3 eyes showed minor (1/4) haze that had resolved at month 1. 3/30 eyes demonstrated an IOP spike and 13/30 eyes required more than 5 days for the epithelial defect to close (P<.1).


Topo-PRK combined with Topo-CXL and oxygen supplementation appears to be relatively safe in a pilot study setting and possibly achieves a better refractive and topographic outcome than regular CXL.

Financial Disclosure:


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