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Effect of vitamin D supplementation on the ocular surface of patients with vitamin D deficiency

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Session Details

Session Title: Ocular Surface & Quality of Vision

Session Date/Time: Monday 24/09/2018 | 14:00-16:00

Paper Time: 14:18

Venue: Room A3, Podium 1

First Author: : E.Karaca TURKEY

Co Author(s): :    O. Evren Kemer   D. Ozek   D. Berker              

Abstract Details


Vitamin D deficiency is a common health problem worldwide and vitamin D is known to have anti-inflammatory action. Ocular inflamamation is the leading problem in dry eye patients. In this study we aimed to investigate the effect of vitamin D replacement on the ocular surface of patients with vitamin D deficiency.


Health Sciences University Ankara Numune Training and Research Hospital


A total of 40 patients (34 females, six males, mean age: 48,4 ± 11,075 years) with vitamin D deficiency followed by the Endocrinology and Metabolism Department of Ankara Numune Training and Research Hospital were enrolled in the study. Patients were given 50.000 units of oral vitamin D weekly, over a period of eight weeks. After eight weeks, 1500-2000 units/d were prescribed for 6 months. Eyelid margin score, meibomian gland exspressibility score, Oxford grading, Schirmer I test, tear break up time (TBUT), tear osmolarity and ocular surface disease index (OSDI) score were evaluated at baseline, eighth week, third and sixth month.


Meibomian gland exspressibility score, Schirmer, TBUT, tear osmolarity and OSDI scores showed improvement at 8 weeks after vitamin D supplementation compared to baseline values (p<0,05, paired t test). This improvement was maintained at third and sixth months. Compared to pretreatment values, eyelid margin score and Oxford grading were decreased at third month. (p<0,05, paired t test)


Vitamin D replacement improves the health of ocular surface and leads to decrease the symptoms of the patients related to dry eye.

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