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Clinical analysis of bacterial keratitis according to culture positivity

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Session Details

Session Title: Infections

Session Date/Time: Sunday 23/09/2018 | 16:30-18:00

Paper Time: 16:48

Venue: Room A3, Podium 3

First Author: : S.Lee SOUTH KOREA

Co Author(s): :    C. Cho   D. Kim                 

Abstract Details


To compare the epidemiology, predisposing factor, clinical characteristic, and treatment outcome of the patients with bacterial keratitis according to culture positivity.


Retrospective, case-control study. All of study cases were taken by Department of Ophthalmology, Yeungnam University College of Medicine, South Korea.


Ninety-three eyes of inpatients with bacterial keratitis between January 2012 and December 2016 were reviewed retrospectively. Total cases were divided into two groups, culture positive (CP, 34 eyes) and culture negative (CN, 59 eyes) group. Epidemiology, predisposing factor, clinical characteristic, and treatment outcome were compared between two groups. Poor clinical outcome was defined as final BCVA worse than 20/200, or decreased VA during treatment, or complications, or requiring surgical intervention.


Pseudomonas species (12 eyes) and Staphylococcus species (11 eyes) were common isolates in CP group. Culture positivity was higher in spring/summer than in autumn/winter (46.7%:23.4%; p=0.017). There was no difference of mean age, sex, corneal trauma, and contact lens wear between two groups. Prior topical antibiotics use (54.5%:68.9%; p=0.168) was higher in CN group. In CP group, epithelial defect size ≥5mm2 (55.9%:30.5%; p=0.016), epithelial healing time >14 days (17.6%:1.7%; p=0.009), and surgical intervention (14.7%:3.4%; p=0.095) were more frequent than in CN group. Poor clinical outcome was occurred in 12 cases, and there was no difference between two groups (16.1%:9.8%, p=0.492).


There was no significant difference of predisposing factors and epidemiologic factors between CP and CN groups. This study showed the seasonal variation in culture positivity of bacterial keratitis. CP group revealed relatively worse initial clinical characteristics and worse clinical course than in CN group. However, culture positivity itself was not significantly associated with poor clinical outcomes.

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