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Relationships between biochemical factors of endothelial dysfunction and morphometric indicators of macular retina in women with pre-eclampsia

Poster Details

First Author: O.Kolenko RUSSIA

Co Author(s):    N. Pomytkina   E. Sorokin   G. Chizhova   Y. Berdakov           

Abstract Details


Preeclampsia is characterized by multiple organ disorders. It is caused by generalized endothelial dysfunction, which is formed by increasing the vasoconstrictor endothelin (E) in the blood. This contributes to vasospasm, increased aggregation of blood cells. Purpose: to study the presence of a relationship between the level of E, von Willebrand factor and morphometric parameters of the macular retina in pregnant women with preeclampsia.


The work was performed in the Khabarovsk branch of the Federal State Autonomous Institution «S.N. Fedorov National Medical Research Center «MNTK «Eye Microsurgery» of the Ministry of Health of the Russian Federation


42 pregnant women with varying degrees of severity of PE, aged from 21 to 40 years. The level of E in tear fluid, the content of von Willebrand factor, and the macula volume (MV) of the were studied. Studies were performed during the 3rd trimester of pregnancy.


By the 3rd trimester, there was a clear tendency to increase in the levels of E in tear fluid, VWF in blood and MV indicator, correlative with the degrees of preeclampsia severity. E ranged from 1.3±0.2 to 3.2±0.3 ng/ml; VWF - from 88.9±7.3% to 157±9.5%. MV indicator varied from 6.4 to 9.5 mm3. Strong direct statistically significant relationship was found between the elevation of the E, VWF in blood serum on the one hand, and the MV on the other (correlation coefficients from 0.71 to 0.83).


The formation of macular edema in moderate and severe preeclampsia in the 3rd trimester, even with its subsequent reduction, can adversely affect retinal metabolism, creating a favorable background for the development of macular pathology in the postnatal period.

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