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Spontaneous disappearance of cornea verticillata of unknown etiology

Poster Details

First Author: K.Yatsui JAPAN

Co Author(s):    S. Koh   T. Hamano   M. Ichii   N. Maeda   K. Nishida        

Abstract Details


To describe the case of a patient who exhibited bilateral cornea verticillata of unknown etiology without any systemic disease or medications, which resolved spontaneously.


Osaka University Hospital, Osaka, Japan


A case report.


A 41-year-old woman had cornea verticillata, a whorl-like pattern of corneal opacities. She had experienced symptoms of photophobia 2 months prior. There was no ocular history in her eyes. She did not use any eye drops, medications or supplements. There were no other abnormal findings in either the anterior or posterior segments. She underwent a systemic investigation including lysosomal enzymes and genetic testing of Fabry disease; all test results were normal. When she returned to our clinic for follow-up assessment a year later, there were no cornea verticillata; both corneas had a normal biomicroscopic appearance.


We believe this to be the first case report documenting the occurrence and spontaneous resolution of temporary cornea verticillata. Our case highlights the possible onset of cornea verticillata in the eyes of patients without any systemic disease or medications. Although etiology of transient cornea verticillata remains obscure, further long-term observation is required to elucidate the mechanism.

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