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Lamina cribrosa thickness in patients with keratoconus

Poster Details

First Author: D.Ulusoy TURKEY

Co Author(s):    Z. Duru   -. -   -. -              

Abstract Details


To evaluate the thickness and depth of lamina cribrosa (LC) in the optic nerve head region of the eyes in patients with nonglaucomatous keratoconus and to compare the thickness and depth with those of age-matched controls.


cross-sectional study


This was a cross-sectional, observational study comprising 40 patients with keratoconus and 40 healthy subjects. Analysis of LC imaging was performed using spectral domain optical coherence tomography. Data collected included spherical equivalent, central corneal thickness, axial length, intraocular pressure, and keratometry.


Eyes with keratoconus had significantly thinner LC (166,6±18 vs. 245,6±10,4 μm, P = 0.000) compared with control group eyes. There was no statistically significant difference in the depth of LC between the keratoconus and control groups (P = 0.91). Multivariable analysis, controlled for age and sex, showed that the thickness of LC significantly correlated with central corneal thickness and keratometry (P = 0.000, P = 0.000, respectively). There was no significant correlation with other factors, including the spherical equivalent axial length,and intraocular pressure (for all, P > 0.05).


The results of this study showed that optical coherence tomography measurement of LC revealed thinner LC for patients with keratoconus compared with healthy controls. The structural properties of the cornea may be related to the optic nerve.

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