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One-year outcomes of trabecular micro-bypass stents with concomitant cataract surgery in primary angle-closure glaucoma

Poster Details

First Author: A.Salimi CANADA

Co Author(s):    M. Abu-Nada   P. Harasymowycz                 

Abstract Details


Trabecular micro-bypass stents have allowed improved multi-directional flow with good efficacy and safety profile in primary open-angle glaucoma. The efficacy of these devices in primary angle-closure glaucoma has been understudied. We aimed to assess the one-year postoperative outcomes following implantation of two first or second generation trabecular micro-bypass stents with concomitant cataract surgery in angle-closure glaucoma patients.


Single surgeon, single urban ophthalmology centre.


We evaluated the baseline clinical characteristics and the 12-month outcomes of patients with mild to severe primary angle-closure glaucoma who underwent cataract surgery with implantation of two first- (iStent group) or second-generation (iStent-inject group) trabecular micro-bypass stents. The primary outcomes included intraocular pressure (IOP) and anti-glaucoma medication use. The secondary outcomes were success rate (defined by IOP between 5-18 mmHg and a minimum reduction of 20%) and visual acuity.


A total of 83 eyes (58 from the iStent and 25 from the iStent-inject group) were included with an average age of 68.9±8.6 and 67.6±8.3 years, respectively. All eyes had mild to severe angle-closure glaucoma. At one-year follow-up, the IOP decreased by 21% (from 18.8±4.5mmHg) and 25% (from 18.7±3.6mmHg), in each group respectively (p< 0.001). Additionally, the medication burden dropped by 52% and 50% at one-year follow-up (p< 0.001). The 12-month success rate was 45% in the iStent group compared to 64% in the iStent-inject group (p=0.086) and visual acuity remained stable.


The present study provides clinically relevant, real-world data on the utility of both iStent and iStent inject with cataract surgery in angle-closure glaucoma – a population that has been understudied in the world of trabecular micro-bypass stents. Our data demonstrated efficacy of these stents in reducing intraocular pressure and medication burden among patients with primary angle closure glaucoma.

Financial Disclosure:

... receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented

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