Official ESCRS | European Society of Cataract & Refractive Surgeons


Conjunctival goblet cell density following cataract surgery: dry eye syndrome

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Session Details

Session Title: Cataract Surgery: Complications & Management

Session Date/Time: Tuesday 17/09/2019 | 14:00-16:00

Paper Time: 15:40

Venue: Free Paper Forum: Podium 1

First Author: : E.Stangogianni Druya GREECE

Co Author(s): :    C. Stangogianni                             

Abstract Details


To determine the effects of topical dexamethasone with concomitant application of topical serum autologous 20% on the conjunctival goblet cell density in eyes after cataract surgery




DESIGN: A prospective, longitudinal, interventional and comparative study PARTICIPANTS: One hundred eyes from fifty patients with dry eyes who were scheduled for cataract surgery.


Patients were randomly divided into two groups according to the postoperative topical drugs to be given; Group A (Right eye), dexamethasone alone; Group B (Left eye), dexamethasone and serum autologous 20%. Impression cytology was performed 1 month before surgery and 3 months after the surgery, and the mean density of goblet cells was determined.


The density of goblet cells before the surgery in Group A, was 247.0 ± 178.7 cells/mm2 (mean ± SD), and it decreased significantly to 76.5 ± 66.7 cells/mm2 (mean ± SD) at 1 month after the surgery (P = .002). In Group B, the goblet cell density was not statistically different between before (228.5 ± 106.6 cells/mm2) (mean ± SD) and at 3 month after the surgery (201.3 ± 174.4 cells/mm2,(mean ± SD), P = 0.55).


The conjunctival goblet cell density was significantly reduced because of the inflammatory response to the trauma or the corneal incisions that interrupt the nerve communication afferent to the cornea. Also, the concomitant use of topical serum autologous 20% with dexamethasone drugs are beneficial, especially in cases with postoperative dry eyes.

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