Official ESCRS | European Society of Cataract & Refractive Surgeons


Objective evaluation of anterior chamber inflammation after cataract surgery in patients who underwent intracameral injection of mydriatic drugs (Mydrane®): a pilot study

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Session Details

Session Title: Cataract Surgery: Complications & Management

Session Date/Time: Tuesday 17/09/2019 | 14:00-16:00

Paper Time: 15:16

Venue: Free Paper Forum: Podium 1

First Author: : C.Cagini ITALY

Co Author(s): :    A. Cerquaglia   S. Travaglini   M. Lupidi   T. Fiore                    

Abstract Details


To investigate if the intracameral injection of a standardized ophthalmic combination of tropicamide 0.02%, phenylephrine 0.31% and lidocaine 1% (Mydrane®) could determine an abnormal degree of inflammation in the anterior chamber after uncomplicated cataract surgery.


Department of Surgical and Biomedical Science, Section of Ophthalmology, University of Perugia, Perugia, Italy


36 patients who underwent cataract surgery were enrolled. 19 of them underwent intracameral injection of Mydrane®. The aqueous humour flare was measured with the Kowa FM-500 Laser Flare Meter for each patient: before the surgery, the day immediately after and then after 15, 30 and 60 days. Optical coherence tomography (OCT) was also performed in all the patients in order to evaluate if central macular thickness changes occurred during the entire follow-up. The same parameters were evaluated in a control group of 17 patients in which mydriasis was obtained through the use of a routinely used ophthalmic insert (Mydriasert®).


There was no statistically significant difference in terms of aqueous humour flare values between the two groups (p>0,05). In both groups, the highest score of flare was detected in the first day post surgery, with a rapid decrease after 15 days. There were no statistically significant differences between the mean flare values measured 30 and 60 days after surgery and those values that were measured in the preoperative evaluation. No significant variation of the central macular thickness was observed in both groups during the entire follow-up (p>0,05).


Intracameral injection of mydriatic drugs seems not to determine any increase of the anterior chamber inflammatory reaction after cataract surgery. Mydrane® seems to be a safe alternative to traditional mydriatic regimes, allowing a better optimization of the surgery schedule

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