Official ESCRS | European Society of Cataract & Refractive Surgeons


Continued long-term flattening following accelerated cross-linking for keratoconus

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Session Details

Session Title: Corneal Cross-Linking

Session Date/Time: Monday 16/09/2019 | 16:00-18:00

Paper Time: 16:12

Venue: South 5

First Author: : M.Leucci UK

Co Author(s): :    B. Allan   D. Gore                          

Abstract Details


To estimate the prevalence of continued long term corneal flattening after accelerated cross-linking for progressive keratoconus


Moorfields Eye Hospital, London


Prospective, uncontrolled case series of eyes with progressive keratoconus, defined by more than 1.5 dioptre (D) increase in Kmax. Eyes with a minimum stromal thickness of less than 375 µm were excluded. Riboflavin 0.1% soak duration was 10 minutes followed by UVA exposure at 30 mW/cm2 for 4 minutes (total energy 7.2 mJ/cm2). The primary outcome measure was a sustained, progressive decrease in Kmax over 5 years folllow-up.


55 eyes met the inclusion criteria for 5 years follow-up of which 1 eye exhibited sustained, progressive flattening. Baseline Kmax was 55.2 D, reducing to 54.1 D (1 year), 52.8 D (2 years) and 50.8 D (5 years). The prevalence is estimated at 1.8%.


Continued long term flattening following accelerated cross-linking is less common than following Dresden-protocol cross-linking.

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