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Simultaneous LASIK and accelerated collagen cross-linking: six month results including morphological changes observed by confocal microscopy

Session Details

Session Title: Cross-Linking II

Session Date/Time: Tuesday 11/09/2012 | 16:30-18:30

Paper Time: 17:42

Venue: Brown Hall 3 (South Wing, Level 2)

First Author: : M.Mita JAPAN

Co Author(s): :    Y. Yamamoto   M. Tomita           

Abstract Details


Collagen Crosslinking (CXL) is a new method to treat or prevent the development of keratoconous and keratoectasia by strengthening the biomechanical stability between the collagenous strands of the cornea. In this study, we report the six months clinical results of simultaneous LASIK and accelerated CXL using KXL? system (Avedro, Inc). The combination of LASIK and KXL system is called LASIK Xtra? by Avedro, Inc.


Shinagawa LASIK Center, Tokyo, Japan


Twenty three myopic patients underwent bilateral LASIK and then had CXL performed on their non-dominant eye only. Preoperative manifest refraction spherical equivalent was -4.4±2.3 Diopters (D) for the LASIK Xtra? eyes and -4.4±2.3 D for the LASIK only eyes. After LASIK, a one minute riboflavin pre-soak was applied to the corneal bed and then the riboflavin was rinsed away, after which the flap was returned to its original position. Using the KXL system, 30mW/cm2 ultraviolet A light was then applied for 75 seconds. The changes in visual acuity, Keratometric reading, epithelial cell density (ECD) count, and the morphological change by confocal microscopy were investigated.


Uncorrected distance visual acuity (UDVA) at six months postoperative was LogMAR -0.19 (Snellen 20/12.5) for the LASIK Xtra? eyes and LogMAR -0.20 (Snellen 20/12.5) for the LASIK only eyes (P=0.5327). There were no statistically significant differences found between the LASIK Xtra? and the LASIK only?groups at six months in terms of UDVA, Keratometric reading (P=0.8949), or the ECD change(P=0.8864). In the LASIK Xtra? eyes, typical post CXL corneal morphologic change was observed by confocal microscopy images. No intra or postoperative complications were observed.


Six months results suggest that LASIK Xtra? surgery is as safe and effective as regular LASIK. Long term follow-up studies are necessary to confirm this conclusion.

Financial Disclosure:

One or more of the Authors... travel has been funded, fully or partially, by a company producing, developing or supplying the product or procedure presented

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