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Comparison of objective optical quality measured by OQAS (Optical Quality Analysis System) after eyedrops instillation in patients with moderate dry eye: physiological saline vs artificial tears

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Session Details

Session Title: Presented Poster Session: Cornea IV

Venue: Poster Village: Pod 3

First Author: : G.Vandermeer FRANCE

Co Author(s): :    P. Pisella   Y. Chami           

Abstract Details


Dry eye is defined in particular by a tear film instability. This lacrimal instability results in a fluctuations of optical quality. Variability in quality of vision can be demonstrated using a double pass aberometer type OQAS (Optical Quality Analyzing System, Visiometrics). The aim of this work is to compare fluctuations of objective quality of vision measured by OQAS between a treatment with physiological saline eyedrops and a treatment with carmellose 0.5% and hyaluronic acid 0,1% in patients with moderate dry eye syndrome (Optive Fusion (OF), Allergan).


Departement of Ophtalmology, University Hospital of Tours, Tours, France


Optical quality was measured by evaluating the variations of the Optical Scattering Index (OSI) over 20 seconds using the OQAS. Inclusion criteria were a dry eye syndrome with an ocular surface disease index (OSDI) score > 23. Patient was his own control: OF in one eye and physiological saline in the other eye. OSI variations were measured in each eye before instillation, 5 minutes and 2 hours after instillation. Patients were asked not to take any eye drops during 24 hours prior to measurement. Primary endpoint was OSI fluctuations. Secondary endpoints were the number of blinks and the patient preference.


Preliminary results were obtained on 21 patients. Average OSDI score was 36,8. Before instillation, there was no significant differences between “physiological saline” and “OF” eyes for OSI variability and number of blinks. In controlled eye, there were no significant variations for mean OSI, OSI variability, OSI slope, number of blink. In 'OF' eye, there was a significant variation between initial and 2-hour OSI variability (0.22 versus 0.14, p = 0.05), the average slope of OSI (0.04 versus 0.01, p = 0.02) and the number of blinks (4.2 versus 2.8, p = 0.04). 65% of patients prefer the OF eye.


Objective quality of vision mesured by OQAS is an interesting parameter for evaluating the effectiveness of a lacrimal substitute. Objective of artificial tears is, among other things, to provide comfort and a reduction of dry eye symptoms such as poor quality of vision. This study demonstrate that 0.5% carmellose and 0.1% hyaluronic acid allowed a better stabilization of tear film and thus a significantly improvement of the quality of vision compared to physiological saline.

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