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To evaluate ocular surface damage and tear function test in patients with Grave’s disease

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Session Details

Session Title: Presented Poster Session: Cornea IV

Venue: Poster Village: Pod 3

First Author: : N.Paharia INDIA

Co Author(s): :    I. Arora              

Abstract Details


Dry eye is the most frequent cause of ocular discomfort In TAO and role of T cell dependent inflammation has been implicated in the pathogenesis. The purpose of our study is to prove that T cell dependent inflammation contributes to the dry eyes in patients with grave disease prior to proptosis and lid lag, which has been described as main cause of dry eyes in TED. Impression cytology is standard technique to study squamous metaplasia of conjunctiva and goblet cells loss in ocular surface disorder


Mahatama gandhi Medical college Jaipur, India


Study Design: Prospective Interventional/ observational Study Study Site: Mahatma Gandhi Hospital, Jaipur Study Period: 12 months Inclusion criteria: 25 newly diagnosed patients of Graves disease ( Group 1) and 25 healthy subjects (group 2) were selected Both the groups examined for visual acuity, lid lag, palpebral fissure width, Proptosis, Ocular motility and fundus Schirmers test (without topical anaesthesia) TBUT, OSDI were performed Impression cytology was done from the temporal interpalpebral bulbar conjunctiva and graded according to Nelson grading


Patient with hyperthyroidism were more symptomatic for dry eyes as compared to control. Mean OSDI score in the patient group was 47.2+-12 as compared to 26+-10 in control group. Mean Schirmer test score was 12.62+- 5.26 in cases as compared to 22.64+-5.6 in control group. Mean Tear Film Break up Time (TBUT) was 7.28+-3.1 second in cases as compared to 10.64+-1.6 seconds in control. Impression Cytology: grave’s patients showed significant Ocular Surface damage in which 78% had grade 2-3 squamous metaplasia in temporal inter-palpebral conjunctiva in comparison to control.


Proptosis and Lid retraction are not only the pathological cause for dry eyes. Ocular surface inflammation characterised by metaplastic changes also contribute to the pathogenesis of dry eyes in patients of hyperthyroidism.

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