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Accelerated corneal collagen cross-linking (CXL) versus conventional corneal CXL for progressive keratoconus

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Session Details

Session Title: Presented Poster Session: Cornea IV

Venue: Poster Village: Pod 3

First Author: : B.Kambo ALBANIA

Co Author(s): :    A. Belshi              

Abstract Details


To compare the outcomes of accelerated corneal collagen crosslinking (CXL) and conventional corneal crosslinking for progressive keratoconus .


Laser Eye Clinic, Continental Hospital , Tirana Albania


Patients were divided into two groups as the accelerated CXL group and the conventional CXL group. Eyes with progressive keratoconus had accelerated CXL (KXL system Avedro System; 10 minutes riboflavin ,Vibex Rapid, presoak; 8 minutes 30 mW/cm2, 7,2 mJ ultraviolet-A UVA light, puls 1sec on , 1 sec off ) or conventional CXL, 30 minutes riboflavin Vibex , presoak; 30 minutes 3 mW/cm2 UVA light). The postoperative changes in visual acuity, keratometric values , morphologic changes in the cornea, demarcation line existence, with accelerated CXL and conventional CXL were compared. The follow-up was 1 year.


The study enrolled 28 eyes of 18 patients,18 eyes had accelerated CXL,and 10 eyes had conventional CXL.The mean UDVA and CDVA were better at the six month postoperative when compared with preoperative values in two groups. There were no statistically significant differences in postoperative changes in uncorrected or corrected distance visual acuity or in the manifest refraction spherical equivalent between the 2 procedures.There were also no statistically significant differences in the postoperative changes in the keratometric value and mean corneal power between the procedures. Similar morphologic changes and a pronounced demarcation line were apparent in eyes in both groups postoperatively.


Accelerated and conventional CXL were both safe and effective.Refractive and visual results of the accelerated CXL method and the conventional CXL method for the treatment of progressive keratoconus were similar. Accelerated CXL, being a fast procedure, appears to be more beneficial for patients and surgeons.

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