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Comparison of clinical outcomes between Dresden and accelerated corneal cross-linking in cases of progressive keratoconus

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Session Details

Session Title: Presented Poster Session: Cornea IV

Venue: Poster Village: Pod 3

First Author: : T.Kojima JAPAN

Co Author(s): :    M. Morikawa   Y. Yoshida   T. Nakamura   Y. Satoh   K. Ichikawa  

Abstract Details


To compare the clinical outcomes between the Dresden protocol and accelerated corneal crosslinking (CXL) in cases with progressive keratoconus.


Nagoya Eye Clinic, Nagoya, Japan Satoh Yuya Eye Clinic, Sendai, Japan


Sixty-seven eyes of 56 Japanese patients with progressive keratoconus who underwent corneal crosslinking and were followed-up for 1 year were enrolled in this retrospective comparative study. The Dresden protocol involved application of riboflavin, then ultraviolet (UV) light (3 mW/cm2) irradiation for 30 minutes. Accelerated crosslinking comprised UV irradiation (KLX system, Avedro; 18 mW/cm2) for 5 minutes. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), average keratometric power and cylinder (measured by TMS4, TOMEY), and postoperative complications were compared between the 2 groups. Friedman test was used for statistical analyses with p<0.05 indicating statistical significance.


The mean UDVA and CDVA in both groups significantly improved 1 year after surgery (UDVA: pDresden=0.007, pAccelerated CXL=0.023; CDVA: pDresden =0.027, pAccelerated CXL= 0.016). The mean average K in both groups significantly decreased 1 year after surgery (Dresden: from 48.5±4.5D to 47.5±4.3D, p=0.037; accelerated CXL: from 49.5±5.9D to 47.7±4.7D, p=0.022). Corneal refractive cylinder and corneal endothelial cell densities in both groups were not significantly different before and 1 year after surgery. At the 1-year follow-up visit, 5 eyes in the Dresden group and 1 eye in the accelerated CXL group showed faint deep stromal opacity.


The study revealed that the Dresden protocol and accelerated CXL have equivalent treatment effects in patients with progressive keratoconus.

Financial Disclosure:

receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented

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