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Evaluation of tear film osmolarity and other signs of dry eye in patients with keratoconus with and without intracorneal ring segment implantation

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Session Details

Session Title: Presented Poster Session: Cornea III

Venue: Poster Village: Pod 2

First Author: : C.Peris-Martinez SPAIN

Co Author(s): :    E. Fernandez-Lopez   M. Roig-Revert   M. Garcia-Domene   A. Diez-Ajenjo     

Abstract Details


To evaluate the quantity and quality of tear film before and after the implantation of intracorneal rings in patients with keratoconus (KC) and compare it with healthy subjects.


FISABIO Oftalmología Médica (FOM). Cornea and Anterior Segment disesases Unit University of Valencia


A total of 23 KC eyes (KC group, n = 23 eyes), 29 KC eyes with intracorneal ring implants (KC with ICRS group, n = 29 eyes) and 23 healthy subjects as a control group (CG, n= 23 eyes) were enrolled in this study. The parameters studied were: Osmolarity (TearLabTM) and other signs of drye eye like tear break-up time (TBUT), Schirmer I test with no anesthetic, ocular surface staining characteristics with lysamine green, Visual Analog Scale. Symptoms of discomfort, Eye Surface Disability Questionnaire with ocular surface disease index (OSDI®). Statistical significance was set at p < 0.05.


The differences in osmolarity evaluated, were statistically significant (p < 0.05) comparing the three groups. Mean osmolarity in KC group were 320.8 ± 10.35 mOsm/l in the KC group, 295.34 ± 10.2 mOsm/l in the KC with ICRS group and 299.13 ± 7.42 mOsm/l in the CG. We found no statistically significant differences in TBUT between groups and lysamine staining between groups.


Intracorneal rings may play a role in improving the quality and distribution of the tear film in patients with keratoconus. This may lead to a greater ocular comfort, reducing the rubbing habit and thus slow the progress of the disease closing a vicious circle.

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