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Preoperative and postoperative nepafenac 0

Poster Details

First Author: A.Toprak TURKEY

Co Author(s):    H. Sivrikaya              

Abstract Details


To compare the efficacy of preemptive and post-operative use of nepafenac 0,1% with placebo for the prevention of pain in post PRK patients.


Dünya Göz Hastanesi Antalya Branch. Zafer mah. Yıldırım Beyazıd Cad. No:93 Kepez-Antalya/Turkey


In this randomized contralateral eye study, adults undergoing PRK surgery were randomized to receive either nepafenac 0,1% or placebo to the right or left eye. Placebo and the study drug were applied 1 hour before surgery, and four times daily for the first postoperative day, the placebo and nepafenac 0,1% were discontinued thereafter. Patients were educated how to score the severity of pain using a visual analog scale (VAS). The forms were collected when the patients came back to office for the removal of the bandage contact lenses and the degree of epithelization was graded.


There were 18 patients in the study, the age of the patients were 25,6+/-3,9 (mean+/-std. dev) the mean spherical equivalent of the right eyes were -2,1+/-1,4 (mean+/-std. dev) and -2,5+/-1,5 (mean+/-std. dev) for the left eyes, respectively. Comparison of placebo treated eyes and nepafenac 0,1% treated eyes on any time following the surgery and on the first postoperative day showed no significant difference. There was no significant difference in terms of epithelization on the third postoperative day.


There are studies showing a decrease of VAS scores in eyes pretreated with nonsteroidal anti-inflammatory drops or when these drops used postoperatively. Although some of our patients reported that the treated eyes were somewhat more comfortable, this did not lead to significant difference. Further studies for the role of nepafenac 0,1% in terms of pain relief are needed to conclude whether it has a beneficial effect in post PRK patients.

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