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Particular ophtalmological aspects regarding the tuberculostatic treatment – a case report

Poster Details

First Author: R.Tudosescu ROMANIA

Co Author(s):    A. Dumitrescu   I. Careba   R. Buzescu   A. Miruta   T. Lkhagvatseren   C. Radu

Abstract Details


To present the case of a 16 year old patient who had received prophylactic treatment with isoniazid and presented toxic optic neuritis


Emergency University Hospital Bucharest, Ophthalmology Clinic, Bucharest, Romania


The patient presented in our clinic approximately 1 week after the onset of headache, nausea and blurred vision in both eyes. She was under prophylactic treatment with isoniazid for 5 months. Ophthalmic examination revealed that the best corrected visual acuity in both eyes was 20/20. Slit lamp examination and Goldmann tonometry were normal in both eyes. Indirect ophthalmoscopy showed bilateral papillary oedema and tortuous retinal vessels. Color testing visual field examination, OCT, a series of laboratory tests, cerebral computer tomography, neurological and phthiseological consult were also performed. The patient received steroid general treatment and local non- steroidal anti-inflammatory drugs.


6 months later, the best corrected visual acuity in both eyes was 20/20 and the visual symptoms had subsided and fundus examination showed a decrease of the bilateral papillary oedema .


The isoniazid treatment can be a cause of toxic optic neuritis. The particularity of the case is that even a prophylactic treatment with a low dose of isoniazid can be the cause of bilateral optic neuritis, which arises the idea that a collaboration between the ophthalmologist and the phthiseological physician would beneficial in the readjustment of the prophylactic tuberculostatic treatment and in setting a monitoring protocol. Disclosure statement: No financial interest

Financial Disclosure:


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