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Ocular surface squamous neoplasia: a great mimicker clinical features and management

Poster Details

First Author: A.Puiu UK

Co Author(s):    S. Srinivasan              

Abstract Details


To present three cases that underscore the variations in the clinical presentation and management of biopsy proven ocular surface squamous neoplasia (OSSN).


Corneal service, University Hospital Ayr, Ayr, Scotland, United Kingdom.


A 67-year-old male presented with a raised lesion involving 360 degrees of the limbal area with limbal stem cell failure in the right eye. Following intralesional alpha-interferon injection he underwent excision biopsy and autologous limbal stem transplant from the fellow eye. A 81-year-old male was referred with a diagnosis of pterygium in the right eye. Clinical examination revealed a raised creamy lesion involving the limbus. He was treated with topical alpha-interferon for two months. A 68-year-old male was referred with rapidly growing raised lesion involving the limbus in the left eye. Excision biopsy, cryotherapy and amniotic membrane graft were performed.


Case one and three were managed surgically while case two responded to topical therapy with alpha interferon. All the three reported cases had OSSN confirmed by pathology and remained tumour free after treatment, on long term follow up.


OSSN can have varied clinical presentation. A high degree of suspicion is required in diagnosing these cases early. Both medical therapy with alpha interferon and surgical treatment with excision biopsy and cryotherapy to the cut edges of the conjunctiva can be effective. These patients require long term follow up to monitor for tumour recurrence.

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