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Tear lipocalin

Poster Details

First Author: I.Careba ROMANIA

Co Author(s):    D. Gradinaru   A. Chiva   E. Ungureanu   R. Ciuluvica   S. Gradinaru  

Abstract Details


Dry eye is the most prevalent condition seen by the ophthalmologist, particularly in the elderly. The early diagnosis of dry eye is essential, but difficult, because the biochemical changes in the tear film usually occur before any detectable signs. We investigate the potential relationship between symptomatology, tear volume and tear break-up time and lipocalin, lactoferrin and lysozyme concentrations in the tear film in a group of symptomatic dry-eyed postmenopausal (PM) women compared to age-matched controls.


Eye Clinic, Emergency University Hospital, Bucharest, Romania


Sixty six healthy PM females (>50 years of age) were categorized as mild or moderate dry eye (DE), or asymptomatic [non-dry eye (NDE)] based on their responses to the Ocular Surface Disease Index (OSDI) questionnaire. Noninvasive tear break-up time (NITBUT) and Schirmer test were performed. Tears were collected via capillary tube and an eye wash method. Tear lysozyme, lacroferrin and lipocalin concentrations were determined via electrophoresis.


OSDI responses revealed 3 mild DE, 30 moderate DE and 33 NDE. The OSDI total score and sub scores for the DE groups were significantly greater than for the NDE group (p < 0.001). The mild and moderate DE groups exhibited significantly shorter NITBUTs compared to NDE (p < 0.004). No difference in tear lysozyme or lipocalin concentration was found between DE and NDE groups, irrespective of tear collection method, but significant difference was found in lactoferrin concentration (p<0.003). No significant correlations were found between symptoms or signs of DE compared to either lipocalin, lysozyme or lactoferrin concentration.


Within a PM population, lipocalin and lysozyme are invariant, irrespective of the presence and severity of DE symptoms.Lactoferrin though shows a significant decrease. This is a comprehensive study of lipocalin, lactoferrin and lysozyme in dry-eyed PM women and our results suggest that lactoferrin could be used as a biomarker of DE in postmenopausal women. These are partial results. Acknowledgement: This work received financial support through the project entitled 'CERO – Career profile: Romanian Researcher', grant number POSDRU/159/1.5/S/135760, cofinanced by the European Social Fund for Sectoral Operational Programme Human Resources Development 2007-2013.

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