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Combined intracameral and subconjunctival bevacizumab for the management of corneal neovascularization in a case of ocular alkali burn

Poster Details

First Author: A.Vrapciu ROMANIA

Co Author(s):    R. Ciuluvica   A. Dumitrescu   R. Pirvulescu   C. Mitulescu   V. Popescu   S. Gradinaru

Abstract Details


To report the case of a 33-year-old Caucasian man presented at our eye emergency department following a splash injury of the left eye with sodium hydroxide. The pacient developed extensive deep and superficial corneal neovascularization.


Ophthalmology Department of Bucharest Emergency University Hospital


Ophthalmic evaluation included visual acuity (VA), tonometry and complete examination. The patient developed extensive deep and superficial corneal neovascularization, despite proper local treatment. Therefore, after the informed consent, we injected an intracameral dose of 2.5mg (0.1mL) of bevacizumab (25mg/mL) and after two weeks we performed subconjunctival administration (2.5mg of bevacizumab), repetead after another two weeks. The main outcome measures were visual acuity, corneal neovascularization, as well as local and general side effects.


No ocular or systemic adverse events were observed. The visual acuity improved and the corneal neovascularization regressed.


Combined intracameral and subconjunctival bevacizumab injections were effective and safe in improving vision and reducing corneal neovascularization caused by chemical injury. No financial disclosure

Financial Disclosure:


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