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Evaluation of changes in corneal biomechanical properties at different levels of diabetic retinopathy

Poster Details

First Author: G.Seymenoğlu TURKEY

Co Author(s):    D. Akbulut   E. Kurt   E. Baser        

Abstract Details


To evaluate the corneal biomechanical properties due to the glycosylated hemoglobin (HbA1C) levels using the ocular response analyzer (ORA) in patients with type 2 diabetes mellitus (DM).


Celal Bayar University Hafsa Sultan Hospital, Department of Ophthalmology


ORA values were obtained from one randomly chosen eye of 101 subjects with type 2 DM and 40 healthy control subjects with similar age and sex. Subjects were divided into three groups: Group 1: healthy control subjects; Group 2: DM patients with HbA1C less than 7%; and Group 3: DM patients with HbA1C ≥7%. Corneal biomechanical parameters: corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) were measured with ORA. Ultrasound pachymetry was used for measurement of central corneal thickness (CCT).


CRF was found to be significantly lower in Group 1 and 2 when compared with Group 3 (P values for CRF respectively; Groups 1 and 2=0.63, Groups 1 and 3, and Groups 2 and 3, = 0.01). There was no significant difference in terms of CH. CCT was significantly different between Groups 1 and 3 and Groups 2 and 3 (P = 0.01) but was insignificant between Groups 1 and 2. Both IOPg and IOPcc was not statistically different between Groups 1 and 2, and Groups 2 and 3, but was significantly different between Groups 1 and 3 (P=0.038).


In poorly controlled diabetics, CRF and CCT are significantly higher compared with those of the healthy subjects and patients with well-controlled diabetes. These values should be taken into account when measuring IOP values in patients with diabetes mellitus.

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